Potencies of FS on mouse heart AC and on AC1, 2 and 5.

EC50-values of FS on mouse heart AC from wild type (WT) or AC5 knockout (AC5KO) mice and on AC1, 2 and 5. EC50-values were calculated from nonlinear regression of respective FS concentration response curves (Fig.1C and 1D). Data represents the means and the 95% confidence interval (C.I.) of experiments with five mouse hearts from WT and AC5KO mice respectively and of experiments with three independent membrane preparations of AC1, 2 and 5, performed in duplicates. logEC50-values were compared against the logEC50 derived from mouse heart AC from WT mice. Not significant (ns) = p>0.05, ****p<0.0001.