EEG Recordings for: Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures

Engagement of the basal ganglia experimental seizures was first observed almost 75 years ago. However, the role of the basal ganglia’s input nucleus, the striatum, in seizure control is relatively understudied. To address this gap, we used an optogenetic approach to activate and inactivate neurons in the dorsal striatum of rats submitted to the gamma-butyrolactone (GBL) model of absence epilepsy, amygdala kindling model of temporal lobe epilepsy, and pilocarpine-induced Status Epilepticus (SE).  Open-loop (continuous light delivery) optogenetic activation of  dorsal striatal neurons robustly suppressed seizures in all models. By contrast, open-loop optogenetic silencing increased absence seizure expression and facilitated SE onset but had no effect on kindled seizures. In the GBL model, we also tested the effects of closed-loop modulation (light delivery in response to seizure detection). Closed-loop activation reduced duration of spike-wave discharges (SWDs), while closed-loo..., , , # EEG Recordings for \"Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures\"

Dataset DOI: [10.5061/dryad.f7m0cfz6w](10.5061/dryad.f7m0cfz6w)

## Description of the data and file structure

### Files and variables

#### File: Kindling.zip

**Description:** A zip archive with folders containing European Data Format (EDF) electroencephalography (EEG) files for each test session for each subject, organized by group, stimulation frequency, and wavelength of light. Files show a single kindling session for each animal with electrographic activity recorded from a depth electrode implanted into the basolateral amygdala and stimulator feedback (when relevant) showing the timing of light delivery.

Data are organized into folders.

* \"Kindling - GFP\" are recordings from animals injected with a control AAV virus expressing green flourescent protein but no opsin.
* \"Kindling - ChR2\" are recordings from animals injected with AAV coding for channelrhodopsin-2 (ChR2) to acti...,