Parameters calculated from chemical denaturation and ANS binding experiments for wild-type and apoE3 variants.

Values are means ± SD from three to four experiments.*1p = 0.07,*2p = 0.08,*3p = 0.08,*4p = 0.024,*5p = 0.06,*6p = 0.031xni and xiu are the mid-transition points for the transition from the native to the intermediate state and from the intermediate to the unfolded state respectively.2mni and miu correspond to the slope of the mid-transition points from the native to the intermediate state and from the intermediate to the unfolded state respectively.