Crystal structure of HCV NS3/4A D168A protease in complex with NR02-59
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
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Crystal structure of HCV NS3/4A D168A protease in complex with NR02-59 Descriptor: 1,2-ETHANEDIOL, 1-(trifluoromethyl)cyclobutyl [(2R,6S,12Z,13aS,14aR,16aS)-2-{[6-methoxy-3-(trifluoromethyl)quinoxalin-2-yl]oxy}-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate, NS3 protease, ... Authors: Zephyr, J, Schiffer, C.A. Deposit date: 2020-12-29 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants. J.Med.Chem., 64, 2021
创建时间：
2020-12-29
