Interaction of beta-2-microglobulin (B2M) chain with class I HC

Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.

钙调神经磷酸酶（CNX）与MHC I类HC的结合稳定了后者，并促进了β2微球蛋白成分（B2M）的关联。两个链通过B2M与MHC HC的α3结构域的非共价相互作用而连接。在形成HC:B2M异二聚体之后，MHC复合物从CNX上解离。