Univariate and multivariate analyses combined markers.

Results of Cox proportional hazard univariate and multivariate analyses are shown for combined markers EZH2, BMI1, SUZ12 and H3K27me3, with p-values and hazard ratios with their 95% confidence intervals. Patient groups were made based on the number of markers showing high expression: all low (group 1), one, two or three high (groups 2–4) and all high (group 5). Group 1 was used as the reference group. Covariates included in all multivariate analyses were age at operation, gender, TNM tumor stage, tumor location, tumor size, microsatellite stability (MSS) status, tumor in the follow up and adjuvant therapy. Significant values are shown in bold, p-values showing a trend (between 0.5 and 1.0) in Italic.Univariate and multivariate analyses combined markers.