Wnt and PI3K signaling deregulation in MMR deficient tumors by immunohistochemistry relative to normal small intestine and colon.

1(+) Increased (or equivalent) staining relative to normal mucosa (–) decreased staining.2Nonuniform staining throughout the tumors.3Removal of Msh2 is significantly better by Villin-Cre (small intestine) than by Adenoviral-Cre (colon),Fisher exact P = 0.0026.4Apc is removed significantly in both tumor types relative to normal mucosa, Fisher exact P5β-catenin is significantly upregulated in adenocarcinomas of the small intestine but not in adenomas of the colon, Fisher exact P6The difference in PTEN decrease between the small and large intestinal tumors is not significant, Fisher exact P = 0.0923.7AKT is significantly upregulated in all tumors relative to normal mucosa, Fisher exact P