SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection

We performed single nuclei transcriptomics frontal cortex samples of rhesus macaques 10- and 20-days post-SIV infection, compared to non-infected controls, to understand alterations of cell type specific neural transcriptomes during acute infection period. Overall design: Fresh frozen postmortem frontal cortex samples from non-infected, 10-day post-infection, and 20-day post-infection rhesus macaques were used to generate single nuclei suspensions and the nuclei were processed for the 10x Genomics 3' gene expression assay v3.1.