Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae

Alliance of Genome Resources2026-08-01 收录

酵母衰老机制

非整倍性效应

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Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive

Yeast aging study. Saccharomyces cerevisiae

酵母衰老机制

DNA损伤响应

Wild type and sgs1 null yeast were grown under DNA damaging (with MMS) conditions or without treatment to log phase and their transcriptional profiles compared . The human aging diseases Werner and Bl

NIAID Data Ecosystem40

RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster. Saccharomyces cerevisiae BY4741

酵母衰老机制

核糖体RNA基因

We isolated yeast mutants that grew normally while Fob1 was overexpressed, expecting that some of the mutated genes would be related to the production of a senescence signal that elongates cell cycle,

NIAID Data Ecosystem20

Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation.

酵母基因表达

非整倍性效应

We report the gene expression profile of two polypolid Saccharomyces pastorianus, lager yeast strains, the Group I strain CBS1538 and the Group II strain W34/70. Saccharomyces pastorianus is a hybrid

NIAID Data Ecosystem10

Nuclear tRNA sequestering slows aging by a mechanism similar to dietary restriction. Saccharomyces cerevisiae

酵母衰老机制

寿命调控

Dietary restriction (DR) is the best-characterized intervention for slowing aging, and reduced signaling through the target of rapamycin (TOR) kinase is believed to be one of the key mechanisms by whi

NIAID Data Ecosystem20

Regulation of lifespan by ER stress response mutants*.

酵母衰老机制

内质网应激

*Replicative lifespan data were pooled for strains from both the MATa and MATα ORF deletion collections (See Table S1 for lifespan data obtained for each mating type separately).

Figshare2015-12-02 更新10

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae

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