Yeast 20S proteasome in complex with epoxyketone inhibitor 16

Yeast 20S proteasome in complex with epoxyketone inhibitor 16 Descriptor: (2S)-N-[(2S)-1-[[(1S)-2-cyclohexyl-1-[(2R,3S,6R,7S)-3-methanoyl-2,6-dimethyl-6,7-bis(oxidanyl)-1,4-oxazepan-7-yl]ethyl]amino]-3-(4-methoxyphenyl)-1-oxidanylidene-propan-2-yl]-2-(2-morpholin-4-ylethanoylamino)-4-oxidanyl-butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Maurits, E, Huber, E.M, Dekker, P.M, Wang, X, Heinemeyer, W, Florea, B.I, Groll, M, Overkleeft, H.S. Deposit date: 2024-06-23 Release date: 2024-07-10 Last modified: 2026-01-28 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structure-Based Design of Pan-Selective Peptide Epoxyketones for the Three Human Immunoproteasome Active Sites. J.Med.Chem., 69, 2026