Figure_1.jpg

Bmal1 knockout aggravates bone resorption in the periodontitis group. (a) Bone resorption of the maxilla in each group. Three-dimensional (3D) reconstruction and two-dimensional (2D) CT images are shown. (b) Quantitative analysis of the alveolar bone resorption area. (c) Quantitative analysis of the mean distance from the CEJ to the ABC in each group. (d) Quantitative analysis of bone volume fraction in the first and second molar area. (e) Histological analyses using hematoxylin and eosin staining to identify attachment loss. *p < 0.05, **p < 0.01, ***p < 0.001, N.S.: No statistically significant difference. ABC, alveolar bone crest; CEJ, cementoenamel junction; CT, computed tomography.