Synthesis of Pyridopyrazine-1,6-diones from 6‑Hydroxypicolinic Acids via a One-Pot Coupling/Cyclization Reaction
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Synthesis_of_Pyridopyrazine_1_6_diones_from_6_Hydroxypicolinic_Acids_via_a_One_Pot_Coupling_Cyclization_Reaction/2447971
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资源简介：
A facile one-pot synthesis of 3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-diones (pyridopyrazine-1,6-diones) has been developed which employs a sequential coupling/cyclization reaction of 6-hydroxypicolinic acids and β-hydroxylamines. The transformation proceeds in good yield under mild conditions using O-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU) to both carry out the amide formation and activate the hydroxyl group for intramolecular alkylation.
创建时间：
2016-02-20
