Setx

Predicted to enable RNA binding activity; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Acts upstream of or within circadian rhythm and termination of RNA polymerase II transcription. Predicted to be located in several cellular components, including growth cone; intercellular bridge; and nuclear lumen. Predicted to be active in nuclear body. Is expressed in cerebral cortex ventricular layer and cortical plate. Used to study amyotrophic lateral sclerosis type 4. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human SETX (senataxin). [provided by Alliance of Genome Resources, Nov 2024]

预测具备RNA结合活性；与蛋白质结合活性相同；以及转录终止位点序列特异性DNA结合活性。在RNA聚合酶II转录的启动或过程中发挥作用，位于昼夜节律调控及转录终止的上游。预测该蛋白定位于多个细胞组分之中，包括生长锥；细胞间桥；以及细胞核腔。预测在核体内具有活性。在脑皮层室层和皮质板中表达。被用于研究肌萎缩侧索硬化症类型4。该基因的人类同源基因与肌萎缩侧索硬化症类型4和轴索神经病性小脑性共济失调2有关。与人类SETX（senataxin）同源。[由基因组资源联盟提供，2024年11月]