Genome-wide association studies have uncovered 52 variants at 34 genetic loci influencing susceptibility to age related macular degeneration (AMD), and with a major contribution from complement genes.
C4b-binding protein (C4BP) is an important component in the regulation of the complement system and also binds the anticoagulant vitamin K-dependent protein S. These activities are performed by distin
Complement C3 and C4 play key roles in the main physiological activities of complement system, and their deficiencies or over-expression are associated with many clinical infectious or immunity diseas
a. Genomic position is based on NCBI build 36. b. aa indicates serum complement levels for homozygous carriers of minor alleles, Aa indicates for heterozygous carriers, and AA indicates for homozygous
