Participant characteristics at study entry overall by age category.

Values are median (IQR) or n (%). Significance tests for age differences are general linear models or logistic regression models for continuous and categorical variables, respectively, with age analyzed as a continuous variable. #Data unavailable for either all ESPRIT participants or for a subset of ESPRIT participants who enrolled from the Vanguard studies. *Biomarker summary statistics reflect a subset of the sample (n = 1193, 1253, and 775 for age strata, respectively). %Polypharmacy was considered as use of two or more of the following drug classes hypertensive, hyperlipidaemia, coronary artery disease, osteoporosis, or diabetes. ∧eGFR was available for participants who consented to store blood samples (n = 960, 1011, and 640 for age strata, respectively). cART = combination antiretroviral therapy. NRTI = nucleoside analog reverse transcriptase inhibitor. PI = protease inhibitor. NNRTI = non-nucleoside analog reverse transcriptase inhibitor. eGFR = estimated glomerular filtration rate. hsCRP = high-sensitivity c-reactive protein. CVD = cardiovascular disease. History of CVD event includes history of myocardial infarction, coronary artery disease surgery, or stroke.