EPO receptor signaling

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

促红细胞生成素受体是一种分子量为66千道的肽，属于细胞因子受体家族。该受体在结合促红细胞生成素后发生酪氨酸磷酸化，并与酪氨酸激酶JAK2结合并激活，进而激活包括Ras/MAP激酶、磷脂酰肌醇3激酶和STAT转录因子在内的多种细胞内信号通路。激活的促红细胞生成素受体在红细胞的存活中似乎扮演着关键角色。促红细胞生成素受体的缺陷可能导致红白血病和家族性红细胞增多症。来源：[维基百科：促红细胞生成素受体](https://zh.wikipedia.org/wiki/%E4%BF%83%E7%BA%A2%E8%83%BD%E7%94%9F%E6%88%90%E7%B4%A0%E5%8F%97%E4%BD%93) 此通路基于ScienceSlides。