DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells. Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells

表观遗传调控

肾病与白血病基因功能研究

To examine if loss of FIS1 would alter the H3K27Ac status of leukemic cells, we used shRNA to knock down the expression of FIS1 in leukemic cell line MOLM-13 cells and performed H3K27Ac CHIP-seq to ch

NIAID Data Ecosystem00

DNA dioxygenases Tet2/3 control epithelial differentiation [RNA-seq]

毛囊上皮分化

表观遗传调控

Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes catalyzing 5-methylcytosine oxidation

Alliance of Genome Resources00

Stage-specific Kdm6b-transcription factor partnerships orchestrate temporal precision during stepwise motor neuron differentiation [RNA-seq]

运动神经元

表观遗传调控

Histone modifiers instruct cellular differentiation, yet how they achieve temporal precision remains enigmatic. Here we demonstrate that the H3K27 demethylase Kdm6b acts as a master epigenetic conduct

NIAID Data Ecosystem00

SMYD2 specificly regulate BIX-01294 induced TP53 target genes revealed by RNA-Seq

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