Putative cases where a substitution causes a switch to a binding site that is active in the same condition as the ‘wild-type’.

Nine cases are described where two motifs, which are members of the filtered dataset, differ by one nucleotide from each other, and show significant coherence in a shared biological condition. The mean expression profiles of genes harboring these motifs in their promoters are different (Pearson correlation coefficient < 0.75 and p-value>0.05), implying that the substitution that would switch one motif to the other would cause a binding site switch.