Best-fit parameters for two-state model of gene expression.
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All fits were performed using maximum likelihood optimization (we used Mathematica 8 to perform the fitting). The functional form of the fit consisted of a linear combination of two gamma distribution pdfs, denoted and , with the mixture parameter . The pdf for a gamma distribution is defined by . The pdf is shifted by Δx, determined by the lowest levels detected in each experiment: . The pdf is shifted to the mode of the pdf: . The mixture pdf is given by .
创建时间：
2015-12-02
