ClueGO preliminary pathway analysis involving the 6 candidate genes.

The Cytoscape ClueGO plug-in permitted us to cluster selected candidate genes into common pathways, and detailed results are shown in this table. GO-ID: ID associated to Gene Ontology. GO-Term: specific GO annotation. Ontology Source: databases from which was derived the annotation. Term p-value: statistical significance of predicted annotation. Term p-value Corrected with Bonferroni step down: statistical correction applied to previous statistical association analysis. Group p-value: statistical significance of predicted clustered annotations. Group p-value Corrected with Bonferroni step down: statistical correction applied to previous statistical clustering analysis. GO-Levels: Due to the complex structure of GO tree (directed acyclic graph), the GO terms were placed in several levels. In case of using sources without hierarchical structure (KEGG, REACTOME, WikiPathways), the level it is assigned as -1. GO-Groups: the group or the groups that include the term. % Associated Genes: percentage of the genes from the uploaded cluster that were associated with the term, compared with all the genes associated with the term. Nr. Genes: number of the genes from the uploaded cluster that were associated with the term. Gene Symbols: symbols of genes clustered in the same group.
(XLSX)