Statistical performance of tetramer approach to analysis of cleavages in set of 1369 substrates [10] for MMP-2 and MMP-9.

Only nonredundant sets of peptide substrates have been selected for statistical assessment. The value of K(obs) (M-1s-1) for each tetramer has been calculated as an average value over all redundant entries. The calculations have been performed for three different thresholds related to K-L divergence analysis: a) for RP above 4.5 or 4.7 for MMP-2 or 9, respectively (“selectome”) and b) for RP above 0, which includes all substrates. (XLSX)