PacBio sequencing was used to sequence and assembly genomes from clinical M. tuberculosis isolates. The PacBio genome assemblies were then used to benchmark variant calling performance of short-read I
Genes induced and repressed by functional category at 30 minutes post-diamide treatment in the isogenic mutant. n = 3. MT # and Rv # denote the CDC1551 and the H37Rv gene IDs, respectively.
Tuberculosis (TB) has surpassed HIV as the leading infectious disease killer worldwide since 2014. The main pathogen, Mycobacterium tuberculosis (Mtb), contains ~4,000 genes that account for ~90% of t