Structure of BACE Bound to SCH736062
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Structure of BACE Bound to SCH736062 Descriptor: (4S)-1-(4-{[(2Z,4R)-4-(2-cyclohexylethyl)-4-(cyclohexylmethyl)-2-imino-5-oxoimidazolidin-1-yl]methyl}benzyl)-4-propylimidazolidin-2-one, Beta-secretase 1, D(-)-TARTARIC ACID Authors: Strickland, C, Zhu, Z. Deposit date: 2009-12-21 Release date: 2010-02-16 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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2009-12-21
