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Transcription profiling of human acute myeloid leukemia cells to identify compounds inducing the differentiation of acute myeloid leukemia cells

ChEBI2007-09-20 更新2026-07-21 收录

急性髓系白血病药物研究

转录组诱导分化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-995 数据链接链接失效反馈

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Transcription profiling of human acute myeloid leukemia cells to identify compounds inducing the differentiation of acute myeloid leukemia cells

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创建时间：

2007-09-20

急性髓系白血病药物研究

c-Myc信号通路

The treatment of acute myeloid leukemia (AML) continues to be challenged by relapse and resistance, necessitating the development of novel therapeutic strategies. Toosendanin (TSN), a natural product

NIAID Data Ecosystem70

Discovery of a Potent and Selective FLT3 Inhibitor ( Z )‑ N ‑(5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-4-methyl‑1 H ‑pyrrol-3-yl)-3-(pyrrolidin-1-yl)propanamide with Improved Drug-like Properties and Superior Efficacy in FLT3-ITD-Positive Acute Myeloid Leukemia

FLT3靶向治疗

急性髓系白血病药物研究

Overcoming the FLT3-ITD mutant has been a promising drug design strategy for treating acute myeloid leukemia (AML). Herein, we discovered a novel FLT3 inhibitor 17, which displayed potent inhibitory a

NIAID Data Ecosystem30

Study of the effects of AZA and its combination with autophagy inhibitor, spautin-1 on the transcriptome of AML cell lines [I]. Study of the effects of AZA and its combination with autophagy inhibitor, spautin-1 on the transcriptome of AML cell lines [I]

急性髓系白血病药物研究

转录组药物响应

AZA treatment in AML cell lines led to a delayed expression of ERE transcripts. Autophagy inhibition resulted in a greater abundance of ERE transcripts, triggered pro-inflammatory responses, and impro

NIAID Data Ecosystem20

Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia

急性髓系白血病药物研究

双靶点抑制剂

Nowadays, the simultaneous inhibition of two or more pathways plays an increasingly important role in cancer treatment due to the complex and diverse pathogenesis of cancer, and the combination of the

NIAID Data Ecosystem50

Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1

LSD1抑制剂药物设计

急性髓系白血病药物研究

Post-translational modifications of histone play important roles in gene transcription. Aberrant methylation of histone lysine sidechains have been often found in cancer. Lysine specific demethylase 1

NIAID Data Ecosystem30

Transcription profiling of human acute myeloid leukemia cells to identify compounds inducing the differentiation of acute myeloid leukemia cells

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