Curative effects of dietary lignans on anxiety and depressive disorders in university students through ameliorating gut microbiome

A total of 28 volunteers were recruited and given an oral dose of 6 grams of defatted flaxseed powder daily for 21 days intervention. The Pittsburgh Sleep Quality Index, Hamilton Anxiety Scale, and Self-Rating Depression Scale were used to assess sleep quality, anxiety, and depression before and after the intervention. Fecal samples were collected from the volunteers before and after the intervention for metagenomic analysis.