Mouse transcripts most differentially dysregulated in the perifornical area of ataxin-3 transgenic animals versus control mice.

The perifornical area of 30 wild type and 30 ataxin-3 transgenic mice lacking hypocretin cells were punched (see Fig. S1) and samples pooled to perform microarray experiments. Hcrt-ataxin-3 transgenic mouse dysregulated genes are listed by order of transcript abundance (fold change). Most transcripts were decreased in Hcrt-ataxin-3 mice, some of which are known to be colocalized with hypocretin (NPTX2, dynorphin). Note that IGFBP3, which was identified by expression profiling using human hypothalami, was also decreased in this experiment.