Additional file 2 of Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model

Additional file 2. Other AD markers not affected by CL-316,243 treatment. Relative optical density of proteins normalized on actin measured in detergent-soluble fraction of hippocampus homogenates by Western Blot. Data are represented as mean ± SD, n = 9-12 per group. Abbreviations: AKT: protein kinase B; APP: amyloid precursor protein; BACE-1: beta-secretase 1; GFAP: glial fibrillary acidic protein; GLUT1: glucose transporter 1; GSK3β, glycogen synthase kinase 3β; IDE: insulin degrading enzyme; LRP1: low density lipoprotein receptor related protein 1; PSD95: post-synaptic density 95; RAGE: receptor of advanced glycation end products; sAPPα: soluble α-APP