Sequencing of Human Adenovirus clinical isolates from recent and Reference Genomes. Adenoviridae

We propose to sequence and analyze 100 clinical isolates of HAdV (representing the remaining 24 prototype genomes not sequenced) collected from different current and historical outbreaks. The 100 clinical isolates proposed here are isolates from outbreaks and sporadic cases which will provide insight into the pathoepidemiological dynamics of this human pathogen, including HAdV evolution, pathogenicity, virulence, host and tissue adaptation.