Light-Mediated Asymmetric Aliphatic C–H Alkylation with Hydrogen Atom Transfer Catalyst and Chiral Phosphoric Acid

In
the presence of tetrabutylammonium decatungstate and chiral
spiro phosphoric acid, a light-mediated asymmetric C–H functionalization
of unactivated hydrocarbons with exocyclic enones has been established.
A wide range of cycloalkanes, benzylic, and allylic hydrocarbons are
tolerated. This protocol proceeds via a hydrogen atom transfer/radical
addition/hydrogen abstraction/enantioselective protonation relay process.