Proteomic signatures of the Pacific oyster Crassostrea gigas cellular response to Ostreid herpes virus -1 (OsHV-1) infection: a metabolic response.

To better understand the pathogenesis of OsHV-1 and to determine which cell pathways might be affected during OsHV-1 infection, we used an experimental infection in the Pacific oyster Crassostrea gigas by intra-muscular injection with a low or high load of OsHV-1. Animals were sampled 2 days post-injection (dpi) which corresponds to the incubation period required for OsHV1 to initiate an intense replication phase. Twenty-five abundant proteins linked to infection process were identified using a two-dimensional electrophoresis (2-DE) proteomic approach.