Pten

ENCODES a protein that exhibits ionotropic glutamate receptor binding; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; INVOLVED IN cellular response to ethanol; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; PARTICIPATES IN altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; endometrial cancer pathway; ASSOCIATED WITH acute myocardial infarction; Cardiomegaly; diabetes mellitus; FOUND IN dendritic spine; postsynaptic cytosol; postsynaptic membrane; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine

编码一种表现离子型谷氨酸受体结合、PDZ结构域结合、磷脂酰肌醇-3,4,5-三磷酸3-磷酸酶活性；参与细胞对乙醇的反应、细胞对胰岛素刺激的反应、细胞对类胰岛素生长因子刺激的反应；参与磷脂酰肌醇3-激酶信号通路、磷脂酰肌醇3-激酶-Akt信号通路、子宫内膜癌通路；与急性心肌梗死、心脏肥大、糖尿病密切相关；存在于树突棘、突触后细胞质、突触后膜；与（+）毛果芸香碱、（R）-去甲肾上腺素、（S）-尼古丁相互作用。