Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.
收藏PubMed Central1994-10-25 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC45077/
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资源简介：
The ability of the p53 protein to act as a sequence-specific transcriptional activator suggests that genes induced by p53 may encode critical mediators of p53 tumor suppression. Using a tetracycline-regulated p53 expression system and cDNA library subtraction procedure, we identified several p53-induced gene transcripts in human Saos-2 osteosarcoma cells that are novel on the basis of their size, regulation, and low abundance. Wild-type p53-dependent induction of these transcripts was observed in cells that are growth arrested by p53, as well as in cells that undergo apoptosis upon expression of an inducible wild-type p53 transgene. These results show that p53 activates the expression of numerous response genes and suggest that multiple effectors may play a role in mediating cellular functions of p53. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1994-10-25
