Drug repurposing using mechanistic models of signal transduction machine learning

Name: Drug repurposing using mechanistic models of signal transduction machine learning
Creator: Loucera, Carlos
Published: 2022-02-09T00:00:00+08:00

Zenodo2022-02-09 更新2026-04-07 收录

药物重定向

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https://zenodo.org/record/6020481 数据链接链接失效反馈

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资源简介：

(DREM³L) Drug REpurposing using Mechanistic Models of signal transduction and Machine Learning

提供机构：

Loucera, Carlos

创建时间：

2022-02-09

IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure [ChIP-Seq]

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脂肪组织功能

Signaling pathways that promote adipose tissue thermogenesis are well characterized, but the physiologic limiters of energy expenditure are largely unknown. Here we show that ablation of the anti-infl

干细胞与再生医学数据中心2022-02-20 更新70

Data_Sheet_3_NF-κB and AP-1 are required for the lipopolysaccharide-induced expression of MCP-1, CXCL1, and Cx43 in cultured rat dorsal spinal cord astrocytes.ZIP

神经炎症

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TLR4 and Cx43 signaling in dorsal spinal cord has been shown to be involved in the development of neuropathic pain. However, it is not clear whether TLR4 signaling is associated with the expression of

NIAID Data Ecosystem50

Additional file 12: of Multi-label multi-instance transfer learning for simultaneous reconstruction and cross-talk modeling of multiple human signaling pathways

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蛋白质相互作用网络

Text file contains the derived cross-talk signaling PPIs between human signaling pathways (target instance). (ZIP 17 KB)

Figshare2016-12-15 更新20

Supplemental Table 1.

基因表达分析

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Quantitative real-time PCR of tight junction and noncanonical Wnt signaling pathway-associated genes in WT and Cftr KO freshly isolated crypts and early passage enteroids. Upper, freshly isolated cryp

DataCite Commons2025-04-01 更新60

Skeletal muscle stem cell changes between young and aged. Skeletal muscle stem cell changes between young and aged

干细胞衰老

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To identify signaling pathways differencees between young and aged muscle stem cells Overall design: Muscle stem cells isolated from 2-4 month old mice or 24 month old mice by alpha7+/CD34+ sorting. C

NIAID Data Ecosystem30

Drug repurposing using mechanistic models of signal transduction machine learning

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