Similarity-Based Profiling of Hydrazone-Containing Scaffolds Active Against Leishmania Amastigotes

This review explores
the potential of hydrazone-containing scaffolds
as anti-leishmanial agents with a particular focus on their activity
against intracellular Leishmania amastigotes.
Through a strategy centered on the 3D electroshape properties of compounds,
structural analysis goes beyond the traditional functional group-based
approach, employing molecular alignment techniques to identify key
structural features associated with anti-leishmanial activity. This
review systematically compiled data from previous studies, highlighting
compounds with promising in vitro activity. Structural comparisons
using molecular overlays have enabled the identification of promising
compounds and the exploration of their potential mechanisms of action.
The integration of computational and experimental approaches provides
valuable insights into the rational optimization of hydrazone scaffolds
with the aim of improving efficacy, bioavailability, and safety. However,
complete elucidation of the precise molecular targets and mechanisms
of action remains a crucial challenge for future research. In summary,
this review highlights the potential of hydrazone-containing compounds
as a basis for developing novel therapeutic agents against leishmaniasis
by utilizing a shape-based molecular alignment strategy to drive drug
discovery efforts.