Inhibition of NOS1 but not NOS3 reverses the ISO-dependent increase in SR Ca2+ leak.
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A) Leak/load relationship. B) Matched data such that the average [Ca]SRT was the same for all treatments (left) and resultant leaks (right, n = 13–17). C) Data matched such that the average SR Ca2+ leak was the same for all treatments (left) and the [Ca]SRT needed to induce that leak (right, n = 11–19). *different from control, # different from ISO (t-test, p
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2016-02-23
