In order to understand the transcriptional regulatory program of cardiomyocytes perinatal transition, we mapped chromatin accessibility, transcription-centered long-range chromatin interactions as wel

NIAID Data Ecosystem30

Integrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation [DGE]. Homo sapiens

DNA甲基化与羟甲基化

细胞分化表观调控

5-methylcytosine (5-mC) can be oxidized to 5-hydroxymethylcytosine (5-hmC). Genome-wide profiling of 5-hmC thus far indicated 5-hmC may not only be an intermediate form of DNA demethylation but could

NIAID Data Ecosystem20

Specific methylation marks in promoter regions are associated to the pathogenic process of Chronic Chagas disease Cardiomyopathy by modifying transcription factor binding patterns [RNA-Seq]

心肌病表观遗传学

疾病生物标志物发现

Chagas disease, caused by Trypanosoma cruzi, is an endemic parasitical disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, includi

NIAID Data Ecosystem40

sup. Table S1

扩张型心肌病

DNA甲基化与羟甲基化

5mC and 5hmC genes in the aetiology of dilated cardiomyopathy

Figshare2019-06-01 更新30