Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB503
收藏Protein Data Bank Japan2024-06-26 更新2026-04-19 收录
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Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB503 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-azanyl-5-phenyl-phenyl)-4-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)benzamide Authors: Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2023-06-06 Release date: 2023-07-05 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. Acs Chem.Biol., 19, 2024
创建时间：
2023-06-06
