Exploring Protein Relative Relations in Skeletal Muscle Proteomic Analysis for Insights into Insulin Resistance and Type 2 Diabetes

We performed library-based DIA proteomic analysis of post-exercise skeletal muscle biopsies collected from individuals which spanned a range of glucose metabolism disorders: normal, prediabetes, and T2D. To identify significant protein relations indicative of each specific category, we utilized the Relative Evolutionary Hierarchical Analysis (REHA), which employs interpretable, white-box techniques. [e-mail] [e-mail]