pme-2020-0167 - Supplementary Material - A GRIN3A Polymorphism May be Associated with Glucocorticoid-Induced Symptomatic Osteonecrosis in Children with Acute Lymphoblastic Leukemia

Supplementary Table 1
Associations of combinations of genetic polymorphisms (allele carriers) with
incidence of glucocorticoid-induced grade 4 osteonecrosis

Supplementary Table 2 Odds ratios (95% CI) of glucocorticoid-induced grade 4
osteonecrosis by genotype in intermediate/high risk arm only

Supplementary Table 3 Time (in weeks) to occurrence of glucocorticoid-induced
grade 4 osteonecrosis by genotype in intermediate/high risk arm only

Supplementary Table 4
Dexamethasone (mg/m2) cumulative dose to glucocorticoid-induced grade 4
osteonecrosis by genotype in intermediate/high risk arm only

Supplementary Table 5
Hazard Ratios (95% CI) of time (weeks) and Dexamethasone (mg/m2) cumulative
dose to occurrence of glucocorticoid-induced grade 4 osteonecrosis by
genotype in intermediate/high risk arm only

Supplementary Figure
1 Cumulative incidence of glucocorticoid-induced grade 4 osteonecrosis in
subjects treated with the intermediate/high risk arm by GRIN3A genotype with
cumulative dexamethasone dose (P=0.039 by Log-rank test)