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MitoPark Transgenic Mouse Model Recapitulates Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson's Disease

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP218140
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The MitoPark mouse is a genetic model for Parkinson's disease (PD) that replicates the progressive development of the key symptoms. GI disturbances is an important non-motor symptom which in this model is yet to be explored extensively. This study characterizes GI motility, gut-microbiome dysbiosis, intestinal inflammation and metabolic profile using neurochemical, genomic and metabolomic approaches.
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2019-10-12
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