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Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer)

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Protein Data Bank Japan2024-10-02 更新2026-04-19 收录
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https://pdbj.org/mine/summary/8uv2
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Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer) Descriptor: 3-(4-{[(4P)-5-{[(1R)-cyclohex-2-en-1-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,6-difluorophenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase Authors: Nandi, P, DeVore, K, Chiu, P.-L. Deposit date: 2023-11-02 Release date: 2024-08-21 Last modified: 2024-10-02 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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2023-11-02
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