Additional file 8: of Encircling the regions of the pharmacogenomic landscape that determine drug response

We have chosen 21 features from network-based measures and other functional data: (i) General features (columns 2–9). They illustrate basic and general features derived from the omics panel. We provide, for instance, the number of genes in each module, the average correlation among module genes and a measure of how “unique” are those genes with respect to other modules. Besides, we annotate drug classes and the AUROC predictions in both the GDSC and CTRP panels. (ii) Network features (columns 10–12). These include distances between module genes and drug targets, “connectivity” within module genes (i.e., distance between them), and proximity to genes from other modules. (iii) Biological features (columns 12–21). A series of biological features related to drug biology. We give most of them as simple proportions of genes/proteins. Among others, we provide the cellular compartmentalization of the genes, transcription factor specificity and the proportion of disease-related and “druggable” genes inside the module. Annotated drug targets are listed as well. (XLSX 156 kb)