AVP promotes bone marrow myelopoiesis in depression. AVP promotes bone marrow myelopoiesis in depression

Sympathetic nerves have been implicated in the regulation of HSC homeostasis, we investigated whether sympathetic nerves regulated myeloid-biased differentiation of HSCs in CUMS mice. Transcriptome profiling (RNA-seq) and differential gene expression analysis of bone marrow cells were performed. In bone marrow cells of CUMS mice, the expression of arginine vasopressin receptor 2, a receptor of the stress-related neuroendocrine factor AVP, was upregulated through neuroactive ligand-receptor interaction pathway. Overall design: Total 6 bone marrow samples were analyzed in this study. 3 samples as negtive control, 3 samples as CUMS.