INCREMENTAL PROGNOSTIC VALUE OF ARTERIAL ELASTANCE IN MILD-TO-MODERATE IDIOPATHIC PULMONARY FIBROSIS

PURPOSE: Previous reports suggested that poor pulmonary function was associated with increased arterial elastance (Ea) in patients with chronic obstructive pulmonary disease and systemic sclerosis. The mechanisms connecting pulmonary function and Ea have not yet been accurately studied in patients with idiopathic pulmonary fibrosis (IPF). The present study was designed to assess Ea in IPF patients without chronic severe pulmonary hypertension and to determine its prognostic role over a medium-term follow-up.

METHODS: This retrospective study included 60 consecutive patients with mild-to-moderate IPF (73.8±6.6 yrs, 75% males) and 60 controls matched by age, sex and cardiovascular risk factors. All patients underwent physical examination, spirometry, blood tests, modified Haller index (MHI, chest transverse diameter over the distance between sternum and spine) assessment, conventional transthoracic echocardiography implemented with speckle tracking analysis of left atrial positive global strain (LA-GSA+) and finally carotid Doppler ultrasonography, at basal evaluation. The effective arterial elastance index (EaI) was calculated as the ratio of end-systolic pressure to stroke volume index. During follow-up period, we evaluated the composite endpoint of 1) pulmonary or cardiovascular hospitalizations; 2) all-cause mortality.

RESULTS:  At baseline, EaI was significantly higher in IPF patients than controls (4.1±1.3 vs 3.5±1.0 mmHg/ml/m2, p=0.01). EaI was strongly correlated to the following variables: C-reactive protein (CRP) (r=0.86), forced vital capacity (FVC) (r=-0.91), E/e’ ratio (r=0.91), LA-GSA+ (r=-0.92), common carotid artery-cross sectional area (CCA-CSA) (r=0.89) and MHI (r=0.86), in IPF patients. Mean follow-up time was 2.4±1.3 yrs. During follow-up, 12 patients died and 17 were hospitalized due to major adverse clinical events. At univariate Cox analysis, CRP (HR 1.51, 95%CI 1.25-1.82), FVC (HR 0.88, 95%CI 0.85-0.91), LA-GSA+ (HR 0.85, 95%CI 0.77-0.94), CCA-CSA (HR 1.12, 95%CI 1.03-1.22) and EaI (HR 2.43, 95%CI 1.75-3.37) were significantly associated with outcome. At multivariate Cox analysis, only EaI (HR 1.60, 95%CI 1.03-2.50) retained statistical significance. An EaI ≥4 mmHg/ml/m2 showed 100% sensitivity and 99.4% specificity for predicting outcome (AUC=0.98).

CONCLUSIONS: In patients with mild-to-moderate IPF, an EaI ≥4 mmHg/ml/m2 is a negative prognostic factor over a medium-term follow-up.