Gene expression data from livers of Yap+/+ and Yap+/- mice at postnatal day 30

Liver undergoes both size increase and differentiation during postnatal period, which in mice is approximately first 30 days. The mechanisms of simultaneous postnatal liver cell proliferation and maturation are not clear. In these experiments, role of yes associated protein (Yap), the downstream effector of Hippo Kinase signaling pathway was investigated. Total RNA isolated from livers of Yap+/+ and Yap+/- mice at Postnatal day 30. Pooled livers from 5 mice per genotype were used.肝脏在出生后发育阶段会同时发生体积增大与细胞分化，该阶段在小鼠中约为出生后的前30天。目前学界对于出生后肝细胞增殖与成熟同步进行的分子机制仍未完全阐明。本实验探究了Hippo激酶信号通路的下游效应分子yes相关蛋白（yes associated protein, Yap）所发挥的作用。实验材料取自出生后第30天的Yap+/+与Yap+/-小鼠的肝脏，每个基因型均使用5只小鼠的肝脏混合后提取总RNA。