Non- microdissected tumors with intertumoral heterogeneity indicated by gain and/or loss of molecular alterations during tumor progression.

Surgery: designates the individual center of tumor operation:NL: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.B: Charité Universitätsmedizin, Berlin, Germany.HD: University Hospital, Heidelberg, Germany.#: number of all tumors analyzed.n (P): number of individual tumor pairs.P/R: identifies primary (P) and recurrent (R) tumor of each tumor pair.ID: internal tumor ID.Tissue: abbreviation of diagnosis based on histology.het.: retained heterozygosity.LOH: loss of heterozygosity.pLOH: partial loss of heterozygosity.mut: mutated TP53/IDH1.wt: wild type TP53/IDH1.n.d.: not determined. Bold characters in column:n (P): highlight every second tumor pair of individual patients.P/R: highlight every primary tumor of individual patients.TP53 in detail: highlight the position of individual base exchanges in the affected codon of the TP53- gene.In all remaining columns bold characters highlight tumor pairs with novel molecular alterations during tumor progression. Bold italic characters:Highlight tumor pairs in which molecular alterations of the primary tumor are lost during tumor progression.