GWAS Summary Data of: Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality

Data related to this article: Nat Genet. 2016 Dec;48(12):1557-1563. doi: 10.1038/ng.3708. Epub 2016 Oct 31. Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality. Eppinga RN1, Hagemeijer Y1, Burgess S2, Hinds DA3, Stefansson K4,5, Gudbjartsson DF4,6, van Veldhuisen DJ1, Munroe PB7,8, Verweij N1, van der Harst P1,9,10. Author information Abstract Resting heart rate is a heritable trait correlated with life span. Little is known about the genetic contribution to resting heart rate and its relationship with mortality. We performed a genome-wide association discovery and replication analysis starting with 19.9 million genetic variants and studying up to 265,046 individuals to identify 64 loci associated with resting heart rate (P < 5 × 10-8); 46 of these were novel. We then used the genetic variants identified to study the association between resting heart rate and all-cause mortality. We observed that a genetically predicted resting heart rate increase of 5 beats per minute was associated with a 20% increase in mortality risk (hazard ratio 1.20, 95% confidence interval 1.11-1.28, P = 8.20 × 10-7) translating to a reduction in life expectancy of 2.9 years for males and 2.6 years for females. Our findings provide evidence for shared genetic predictors of resting heart rate and all-cause mortality. PMID: 27798624 DOI: 10.1038/ng.3708 [Indexed for MEDLINE]