S 1. Graph data as supporting information.
收藏DataCite Commons2020-09-04 更新2024-08-17 收录
下载链接：
https://figshare.com/articles/dataset/Differential_relevance_of_NF_B_and_JNK_in_the_pathophysiology_of_hemorrhage_resususcitation_induced_liver_injury_after_chronic_ethanol_feeding/1528228/3
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资源简介：
Hemorrhagic shock and resuscitation (H/R) induce hepatic injury and strong inflammatory changes. Chronic ethanol (EtOH) abuse worsens pathophysiological derangements after H/R. Here, the underlying mechanisms involve JNK and NF-κB activation. In our previous studies, we have shown that inhibiting JNK with a cell-penetrating, protease-resistant peptide D-JNKI-1 after H/R in mice with healthy livers ameliorated H/R-induced harmful changes. In this study, we analyzed if JNK inhibition by D-JNKI-1 in chronically EtOH-fed mice after hemorrhagic shock prior to the onset of resuscitation also confers protection. Our findings show that JNK inhibition is protective only in not pre-harmed liver after H/R. Moreover, the pronounced H/R-induced liver damage in mice being chronically fed with ethanol cannot be prevented by JNK inhibition after H/R and seems to be under the control of NF-ĸB.
提供机构：
figshare
创建时间：
2016-01-20
