Data from: Distinct roles of striatal direct and indirect pathways in value-based decision making

The striatum is critically involved in value-based decision making.
However, it is unclear how striatal direct and indirect pathways work
together to make optimal choices in a dynamic and uncertain environment.
Here, we examined the effects of selectively inactivating D1 receptor
(D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons
(corresponding to direct- and indirect-pathway neurons, respectively) on
mouse choice behavior in a reversal task with progressively increasing
reversal frequency and a dynamic two-armed bandit task. Inactivation of
either D1R- or D2R-expressing striatal neurons impaired performance in
both tasks, but the pattern of altered choice behavior differed between
the two animal groups. A reinforcement learning model-based analysis
indicated that inactivation of D1R- and D2R-expressing striatal neurons
selectively impairs value-dependent action selection and value learning,
respectively. Our results suggest differential contributions of striatal
direct and indirect pathways to two distinct steps in value-based decision
making.