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Inter-myeloid cell synaptic antigen dispersal drives diversified anti-tumor T cell priming

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NIAID Data Ecosystem2026-03-12 收录
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Using a labelled tumor antigen we identify dendritic cell subsets containing tumor derived antigen in the tumor draining lymph nodes and used these to stimulate anti-tumor OTI CD8 T cells. These were subsequently interrogated by RNAseq to determine how diverse DC subsets drive distinct patterns of CD8 T cell differentiation OTI CD8 T cell RNAseq analysis on cells stimulated in vitro by different DC subsets

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2020-11-27
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